Cholestatic liver diseases: Are liver transplant criteria different?
نویسندگان
چکیده
منابع مشابه
Liver Transplantation for Patients with Cholestatic Liver Diseases
BACKGROUND Cholestatic liver diseases (CD) account for 11% of all liver transplantations (LT) in the Eurotransplant region. Despite the excellent long-term outcome that is considerably superior to all other indications for LT, transplant surgeons and physicians face nowadays - in the era of MELD (Model of End-Stage Liver Disease)-based allocation, organ shortage, and extended allocation policie...
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Cholestatic liver diseases are characterized by blockade of bile flow from the liver to the intestine, and accumulation of hydrophobic bile acids in the liver and plasma. As a consequence an inflammatory response evolves associated with increased apoptosis, oxidative stress, and eventually fibrosis. Cholestasis is associated with profound metabolic changes, alterations in the mitochondrial func...
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The goals of post-transplant management are to manage and treat postoperative complications, and develop a balanced long-term immunotherapy regimen that minimizes infection and side effects but controls rejection. While modern immunosuppressant regimes have reduced rates of graft loss due to rejection, they impart major risks for infection, growth failure, metabolic complications, and malignanc...
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Cholestasis can be defined as the accumulation of substances normally excreted in bile (e.g. bilirubin, bile acids, and cholesterol). The process occurs as a result of impaired bile formation by the hepatocytes or from obstruction to the flow of bile through the intra hepatic and extra hepatic biliary tree. The aim of this study was to make laboratory assessment of bone mineral status and detec...
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Familial intrahepatic cholestasis (FIC) comprises a group of rare cholestatic liver diseases associated with canalicular transport defects resulting predominantly from mutations in ATP8B1, ABCB11 and ABCB4. Phenotypes range from benign recurrent intrahepatic cholestasis (BRIC), associated with recurrent cholestatic attacks, to progressive FIC (PFIC). Patients often suffer from severe pruritus a...
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ژورنال
عنوان ژورنال: Indian Journal of Transplantation
سال: 2011
ISSN: 2212-0017
DOI: 10.1016/s2212-0017(11)60072-5